Lefkada is separated from the mainland by a narrow canal crossed by a bridge and a road. Thus, you can drive into Lefkada, quickly crossing over the channel separating the coast of Aitoloakarnania and the island.

The Aktion airport near Preveza on the mainland is about 20 minutes away from Lefkada Town. Many people fly into this airport and then make their way onto the island by car or bus.

The two ports on Lefkada are Vassiliki and Nidri. Vassiliki has a twice-daily connection to Fiskardo on Kefallonia. Boats run once a day from Nidri to both Fiskardo on Kefallonia and to Frikes on Ithaca and from Vassiliki to Aetos on Ithaka.

Buses run every few hours from Lefkada Town to Nidri and Vassiliki, stopping wherever you would like in between. Just tell the bus driver where you are going when you get on and he will most likely make a stop there for you. Water taxis can be taken from Nidri and Vassiliki to the remote beaches along the western coast.